Out Of Service | 20140911

Out Of Service | 20140911 | 1-memo•com | In the morning of 9/11 2001 logistics forced me to officially announce a temporarily – 1 week – ‘out of service’ of our Leiden islet isolation and transplant center. Our center was started earlier that summer of 2001 at the Leiden University Medical Center. So, I decided to have a short vacation abroad – heaven, after being on call 24/7 almost non stop for years. Later that day at home, I was downstairs watching TV — because upstairs near my workroom the central heating was being replaced – when I saw the CNN breaking news about the plane crashing into the World Trade Center. That day would become a landmark in history and the course of my life.

Background image : Microscopy picture I took of purified human Islets of Langerhans – tiny clumps (size around 1/10 mm or 1/25 inch) of 10s to 1000s of cells that produce hormones like insulin – these cells are just visible when you enlarge this 50x microscopy picture : as tiny translucent ‘balls’ or ‘spheres’. The red color is from a stain that binds to the insulin cells.
Iodixanol-UWS purified human islets, stained with dithizone. Original magnification 50x.

Title: mvdb20041118_114555m0400.tif
Creator: Michael P.M. van der Burg
Caption/Description: Iodixanol-UWS purified human islets, stained with dithizone. Original magnification 50x. Copyright Notice: Copyright © 2004 M.P.M. van der Burg. All rights reserved. Digital Creation Date: 18 Nov 2004

References

Image published in : Transplantatie van eilandjes van Langerhans bij patiënten met diabetes mellitus type 1. Ned Tijdschr Geneeskd 2005 1 januari;149(1) – URL https://www.ntvg.nl/system/files/publications/2005100120001a.pdf

Efficacy of the novel iodixanol-UWS density gradient for human islet purification (Presentation publ. Archive Org – michelvanderburg, 19990125 )
https://archive.org/details/EfficacyOfTheNovelIodixanol-uwsDensityGradientForHumanIslet

25 Years of the Ricordi Automated Method for Islet Isolation. Piemonti L, Pileggi A. in CellR4 2013; 1(1): e128. – URL https://www.cellr4.org/article/128

Credit : Out Of Service | 20140911 | 1-memo•com | TakeNode ID e22f209c-14da-40d8-b11a-74a29b1e80b4

TAGS #michelvanderburg #1Memo #oncall #LeidenUniversity #OutOfService #Islet #Langerhans #isolation #purification #transplantation #clinic #human #center #diabetes #CNN #WorldTradeCenter #breakingnews #crash #CV #LUMC #microscopy #dithizone #stain #cell #insulin #therapy #Iodixanol #UWS #UniversityofWisconsin #solution

25 Year Islet Transplants • @1MEMO_20140703

17:35 – Michel enters with transplant.

17:50 – Vygon 6 cannulation

17:52 – 12 mg Heparin IV

17:57 – Transplant

18:00 – 2nd transplant
Activated Clotting Time (ACT) 362″

18:05 – Clamps removed

25 Year Islet Transplants • @1MEMO_20140703 • Michel van der Burg • Miracles•Media • TakeNode c28e9c36-22bc-4409-b26a-2f9f90d9d39b • July 3, 2014 – Holland, Leiden University Hospital, 25 years ago : Photocopy June 13, 1989 surgery journal highlighting the moment of islet transplantion at our start of a first series of succesfull islets graft transplants in the Netherlands, using a simple yet very novel approach that eventually, recently, became a worldwide standard for transplanting clinical grade purified islets in insulin-dependent diabetic patients.
Link to article on the 25 year timeline of progress in research and patient treatment , here : https://www.cellr4.org/article/128 .

Notes

Update 20260319_1021 : adding english translation dutch surgery journal (as quote), and minor text modifications, as part of the process of republishing this post at michelvanderburg.com as part of the science portfolio dd 20260319 https://michelvanderburg.com/category/science/ from the original post at 1-memo•com: 25 Year Islet Transplants | 20140703 | 1-memo.com • URL https://1-memo.com/2014/07/03/25-year-islet-transplants/

#islet #transplantation #diabetes #LUMC #Leiden #history #AZL #UWS #purification #premiere